Make sure to select the correct game install folder if you changed it from default while installing the game. Now, install 'TRAIN_UPDATE1.EXE' or the appropriate version for your language (e.g, 'TRAIN_UPDATE1_DE.EXE' for the German language version).
You should see a dialog box that reads 'atiumdag.dll - File successfully patched! (3 bytes written)'
Use jackfuste's 'MSTS_AMD_BUGFIX.EXE' to create a patched version of an ATI.